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Read e-book online Antihypertensive Therapy: Principles and Practice an PDF

By C. Bartorelli (auth.), F. Gross (eds.)

ISBN-10: 3642502385

ISBN-13: 9783642502385

ISBN-10: 3642502407

ISBN-13: 9783642502408

Hypertension has definitely been one of many subject matters such a lot fre­ quently mentioned at symposia, conferences, and congresses in the course of fresh years. there is numerous purposes for this; 3 of them are visible: to begin with, the truth that a wide share of the world's inhabitants is being affected by quite a few different types of hypertensive affliction; secondly, expanding wisdom of the pathogenesis of high blood pressure and of the disturbances underlying it; and, thirdly, the marked development which has been made in antihypertensive treatment over the last fifteen years. while plans for the current symposium have been being drawn up, it was once felt that it may no longer easily bring about simply one other assembly on high blood pressure, yet may still position specific emphasis on these features which had no longer been effectively mentioned at prior symposia of this sort. interestingly sufficient, the subject which seemed to have obtained least cognizance long ago was once treatment, even though from the sensible standpoint this can be through some distance crucial. the alternative of remedy because the major subject matter of the complete symposium additionally looked to be warranted in view of the really lengthy interval that had elapsed on account that potent antihyper­ tensive remedy grew to become on hand; the time had actually come now to judge the advantages in addition to the shortcomings of drug therapy as to be had today.

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Many derivatives have been synthesised, the main difference between these and the parent compound consisting in substitutions at carbon atom 3, nitrogen atom 2, or the amide nitrogen of the sulphamoyl group in position 7, or in the replacement of chlorine in position 6 by various halogenated alkyls. Compounds involving a substitution at carbon atom 3 are sometimes unstable in solution. Spontaneous hydrolysis within body fluids, which yields the benzene-disulphamoyl derivatives of bendroflumethiazide and trichloromethiazide, may also occur with similar compounds shown in Fig.

It all adds up to the fact that, although we have very effective antihypertensive agents, we are just beginning to unravel their tremendously complex scheme of intermediary metabolites and their actions, particularly in the brain. In a sense it is ironic that 40 years ago I started as a brain chemist and now, after a long lapse into cardiology, find myself again concerned with cerebral metabolism. PAGE: CARLSSON: Dr. PAGE suggested using platelets as a model. Platelets have been used, of course, but I am not sure whether one should concentrate on them.

K. CHEN and B. MUKERJI. Czechoslovac Medical Press, Prague, 1965, 7, p. BEIN, H. , P. A. DESAULLES, and P. LoUSTALOT: Experientia 13, 130 (1957). - BEIN, H. , F. GROSS, J. TRn>OD, and R. MEIER: Schweiz. med. Wschr. 83, 336 (1953). - BENFEY, B. , and D. R. : Brit. J. Pharmacol. 22, 366 (1964). , P. R. HEDWALL, and M. MEIER: Experientia 21, 136 (1965a). , P. R. HEDWALL, and M. MEIER: Experientia 21, 231 (1965b). , and M. LINDQVIST: 28 H. J. BEIN and H. BRUNNER: Mode of action of antihypertensive drugs Acta physiol.

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Antihypertensive Therapy: Principles and Practice an International Symposium by C. Bartorelli (auth.), F. Gross (eds.)


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