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For example, bronchoalveolar epithelium undergoes squamous metaplasia in response to chronic irritation of tobacco smoke' INFTAMMATION AND REPAIR Inflammation enables the body to resist infection. Inflammation occurs in response to injury, which can result from hypoxia, chemicals, drugs, physical agents, microbial agents, immunologic reactions, nutritional imbalances, genetic defects, or aging. The acute inflammatory response occurs over seconds, minutes, hours, and days after the initial insult, whereas the chronic inflammatory response can continue for weeks, months, and even years after the primary injury.

After the particle is engulfed, the phagocytic vacuole fuses with a lysosome, forming a phagolysosome complex. The lysosome disgorges its contents into the fused vacuole. , a bacterium) is then broken down via the action of reactive oxygen species, acid hydrolases, neutral proteases, and lysozyme. b. Chemical mediators of inflammation. Metabolites of arachidonic acid metabolism mediate many of the important aspects of the inflammatory response. , PGI, PGD2, PGE2, PGFr") mediate vasodilatation and pain.

A sex chromosome, iiiBhical 45 Embryology l. Trisomy2l (Down syndrome) a. In some cases, the extra chromosome 21 is translocated or attached to another chromosome. A carrier parent (clinically normal) with 45 chromosomes who has a translocated chromosome 21 has an increased chance of having a child with the syndrome. b. Tiisomy 21 is characterized by mental deficienry, small skull size, upwardly slanting palpebral fissures, and a deep transverse crease across each palm. c. It is associated with an increased incidence of congenital heart defects, umbilical hernia, and duodenal atresia.

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CAS-CERN Accelerator School - General Accelerator Physics (VOL 1)

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